CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients
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چکیده
Julia Hoffmann, Leigh M. Marsh, Mario Pieper, Elvira Stacher, Bahil Ghanim, Gabor Kovacs, Peter König, Heinrike Wilkens, Hans Michael Haitchi, Gerald Hoefler, Walter Klepetko, Horst Olschewski, Andrea Olschewski, and Grazyna Kwapiszewska Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; Institute of Anatomy, University Lübeck, Lübeck, Germany and Airway Research Center North, Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany; Institute of Pathology, Medical University of Graz, Graz, Austria; Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria; Department of Pulmonology, Medical University of Graz, Graz, Austria; Department of Pulmonology, Faculty of Medicine, Saarland University, Homburg/Saar, Germany; Clinical and Experimental Sciences, Faculty of Medicine, University Southampton, UK; NIHR Southampton Respiratory BioMedical Research Unit at University Hospital Southampton, NHS Foundation Trust, UK; and Department of Experimental Anesthesiology, Medical University of Graz, Graz, Austria
منابع مشابه
Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.
Alterations in extracellular matrix (ECM) have been implicated in the pathophysiology of pulmonary hypertension. Here, we have undertaken a compartment-specific study to elucidate the expression profile of collagens and their processing enzymes in donor and idiopathic pulmonary arterial hypertension (IPAH) pulmonary arteries. Predominant intimal, but also medial and perivascular, remodeling and...
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